Department of Dermatology and Venereology, National Medical University, Kiev, Ukraine.
Int J Dermatol. 2012 Mar;51(3):290-4. doi: 10.1111/j.1365-4632.2011.04997.x.
Atopic dermatitis (AD) has an established impact on health-related quality of life (HRQoL) and family QoL.
This study was designed to investigate gender differences in health-related and family QoL in children with AD.
Cohorts of 25 girls and 25 boys with AD aged <4years were selected from 102 children with AD. Children in the girls' and boys' groups were individually matched across groups for age and severity of AD according to their scores on the SCORAD Index (SCORing of Atopic Dermatitis). The children's parents filled in the Infants' Dermatitis Quality of Life (IDQoL) Index and the Dermatitis Family Impact (DFI) questionnaires.
The impact of AD on QoL (P<0.05) and family QoL (P<0.05) was more severe in girls. The severity of AD as assessed by the parents was equal in both groups. More parents of girls reported that AD impacted on the "child's mood" (P<0.05) and "enjoying family activity" (P<0.05). "Child's mood" and "sleep disturbance" were highly scored by parents of girls (P=0.01 and P<0.05, respectively). Severity of AD as assessed by parents and IDQoL Index scores correlated with SCORAD scores in both groups. Scores on the DFI correlated with patient age in boys. The child's age correlated with the emotional distress of parents in both groups and had an impact on "relationships in the family" in girls only. Several DFI items and overall family QoL correlated with patient age in boys.
The impact of AD on QoL and family QoL was more severe for girls. Relationships between parents progressively worsen with patient age in girls. Reported gender differences should be further investigated and may influence educational programs and advice given to parents of children with AD.
特应性皮炎（AD）对健康相关生活质量（HRQoL）和家庭生活质量有明确影响。
本研究旨在调查 AD 患儿的健康相关和家庭生活质量的性别差异。
从 102 例 AD 患儿中选择了 25 例女孩和 25 例男孩 AD 患儿，年龄均<4 岁。根据 SCORAD 指数（特应性皮炎评分）评分，对女孩组和男孩组的患儿进行年龄和 AD 严重程度的个体匹配。患儿的父母填写婴儿特应性皮炎生活质量（IDQoL）指数和皮炎家庭影响（DFI）问卷。
AD 对生活质量（P<0.05）和家庭生活质量（P<0.05）的影响在女孩中更为严重。两组患儿父母评估的 AD 严重程度相同。更多女孩的父母报告 AD 影响了“孩子的情绪”（P<0.05）和“享受家庭活动”（P<0.05）。女孩的父母高度评价“孩子的情绪”和“睡眠障碍”（P=0.01 和 P<0.05）。两组患儿父母评估的 AD 严重程度和 IDQoL 指数评分与 SCORAD 评分相关。DFI 评分与男孩的患者年龄相关。患儿年龄与两组患儿父母的情绪困扰相关，仅对女孩的“家庭关系”有影响。在男孩中，几个 DFI 项目和整体家庭生活质量与患者年龄相关。
AD 对生活质量和家庭生活质量的影响在女孩中更为严重。随着女孩患者年龄的增长，父母之间的关系逐渐恶化。应进一步研究报告的性别差异，这可能会影响针对 AD 患儿的父母的教育计划和建议。
