婴幼儿皮肤病生活质量问卷的反应性及最小临床重要差异
Responsiveness and Minimal Clinically Important Difference of the Infants and Toddlers Dermatology Quality of Life Questionnaire.
作者信息
Chernyshov Pavel V, Marron Servando E, Koumaki Dimitra, Pustišek Nives, Manolache Liana, Salavastru Carmen, Suru Alina, Sendrea Adelina, Svyatenko Tetiana, Statkevych Olha, Boffa Michael J, Grech Sara Borg, Zemskov Sergii, Kuts Volodymyr V, Lishchynskyi Pavlo, Chernyshov Andrii V, Tomas-Aragones Lucia
机构信息
Department of Dermatology and Venereology, National Medical University, Bulvar Shevchenko, 13, Kiev, 01601, Ukraine.
Department of Dermatology, Aragon Psychodermatology Research Group (GAI+PD), University Hospital Miguel Servet, Zaragoza, Spain.
出版信息
Dermatol Ther (Heidelb). 2023 Nov;13(11):2879-2893. doi: 10.1007/s13555-023-01022-x. Epub 2023 Sep 20.
BACKGROUND
The Infants and Toddlers Dermatology Quality of Life (InToDermQoL) is the dermatology-specific proxy health-related quality of life (HRQoL) instrument for children from birth to 4 years. The aim of the present study was to confirm the responsiveness and establish minimal clinically important difference (MCID) for the InToDermQoL.
METHODS
Parents of children with skin diseases were asked to fill in the InToDermQoL at the initial visit (T1) and subsequent consultation (T2). We hypothesized that correlations between change scores of the InToDermQoL and change scores of global assessment of clinical severity by dermatologists and by patients' parents should be above 0.3. The receiver operating characteristic (ROC) curves method was also used for confirmation of responsiveness and determination of MCIDs of the InToDermQoL. The area under the ROC curve (AUC) was used as an indicator of responsiveness.
RESULTS
Results of 442 patients were included. Correlations between change scores of age-specific versions of the InToDermQoL and change scores of global assessment of clinical severity by dermatologists and by patients' parents were above 0.3 (0.46-0.74). AUCs for age-specific versions of the InToDermQoL were acceptable (above 0.7) or excellent (above 0.8). Estimated MCIDs for the InToDermQoL were as follows: 3 points of total score change for 0-11 months, 5 for 1-2 years and 3 or 4 for 3-4 years version. Estimated MCIDs for the InToDermQoL version for 1-2-year-old children was higher than MCIDs for the 3-4-year-old version despite the higher number of items in the latter. Therefore a MCID of 5 was recommended for both these versions.
CONCLUSIONS
Responsiveness for all age-specific versions of the InToDermQoL questionnaire was confirmed. MCIDs for the InToDermQoL are proposed as follows: 3-point change of the total score for age version 0-11 months and 5-point for the age versions 1-2 years and 3-4 years.
背景
婴幼儿皮肤病生活质量量表（InToDermQoL）是针对出生至4岁儿童的皮肤病专用健康相关生活质量（HRQoL）替代工具。本研究的目的是确认InToDermQoL的反应度并确定其最小临床重要差异（MCID）。
方法
患有皮肤病儿童的家长被要求在初次就诊（T1）和后续会诊（T2）时填写InToDermQoL。我们假设InToDermQoL的变化分数与皮肤科医生及患儿家长对临床严重程度的整体评估变化分数之间的相关性应高于0.3。还采用了受试者工作特征（ROC）曲线法来确认InToDermQoL的反应度并确定其MCID。ROC曲线下面积（AUC）用作反应度指标。
结果
纳入了442例患者的结果。InToDermQoL各年龄版本的变化分数与皮肤科医生及患儿家长对临床严重程度的整体评估变化分数之间的相关性高于0.3（0.46 - 0.74）。InToDermQoL各年龄版本的AUC可接受（高于0.7）或优秀（高于0.8）。InToDermQoL的估计MCID如下：0 - 11个月龄版本总分变化3分，1 - 2岁版本为5分，3 - 4岁版本为3分或4分。1 - 2岁儿童InToDermQoL版本的估计MCID高于3 - 4岁版本，尽管后者项目更多。因此，建议这两个版本的MCID均为5分。
结论
确认了InToDermQoL问卷所有年龄版本的反应度。建议InToDermQoL的MCID如下：0 - 11个月龄版本总分变化3分，1 - 2岁和3 - 4岁版本为5分。
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