Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.
Cell Mol Life Sci. 2012 Aug;69(15):2469-83. doi: 10.1007/s00018-012-0928-2. Epub 2012 Feb 15.
Wound repair on the cellular and multicellular levels is essential to the survival of complex organisms. In order to avoid further damage, prevent infection, and restore normal function, cells and tissues must rapidly seal and remodel the wounded area. The cytoskeleton is an important component of wound repair in that it is needed for actomyosin contraction, recruitment of repair machineries, and cell migration. Recent use of model systems and high-resolution microscopy has provided new insight into molecular aspects of the cytoskeletal response during wound repair. Here we discuss the role of the cytoskeleton in single-cell, embryonic, and adult repair, as well as the striking resemblance of these processes to normal developmental events and many diseases.
细胞和多细胞层面的伤口修复对于复杂生物的生存至关重要。为了避免进一步的损伤、防止感染和恢复正常功能，细胞和组织必须迅速封闭和重塑受伤区域。细胞骨架是伤口修复的重要组成部分，因为它需要肌动球蛋白收缩、修复机制的募集和细胞迁移。最近使用模型系统和高分辨率显微镜为伤口修复过程中细胞骨架的分子反应提供了新的见解。在这里，我们讨论了细胞骨架在单细胞、胚胎和成人修复中的作用，以及这些过程与正常发育事件和许多疾病惊人的相似之处。
