School of Physical Education and Sports, University of Sao Paulo, Av Mello de Moraes, 65-Butantã, Sao Paulo, SP, 05508-030, Brazil.
Amino Acids. 2012 Oct;43(4):1803-7. doi: 10.1007/s00726-012-1246-6. Epub 2012 Feb 17.
This study focused on understanding the signaling mechanisms leading to GLUT-4 translocation and increased skeletal-muscle glucose uptake that follow creatine (Cr) supplementation in type 2 diabetes (n = 10). AMPK-α protein content presented a tendency to be higher (p = 0.06) after Cr supplementation (5 g/d for 12w). The changes in AMPK-α protein content significantly related (p < 0.001) to the changes in GLUT-4 translocation (r = 0.78) and Hb1Ac levels (r = -0.68), suggesting that AMPK signaling may be implicated in the effects of supplementation on glucose uptake in type 2 diabetes.
本研究旨在探讨肌酸（Cr）补充后 2 型糖尿病（n = 10）中导致 GLUT-4 易位和骨骼肌葡萄糖摄取增加的信号转导机制。AMPK-α 蛋白含量在 Cr 补充后（12w 内每天 5g）呈现出升高的趋势（p = 0.06）。AMPK-α 蛋白含量的变化与 GLUT-4 易位（r = 0.78）和 Hb1Ac 水平（r = -0.68）的变化显著相关（p < 0.001），提示 AMPK 信号可能与补充对 2 型糖尿病患者葡萄糖摄取的影响有关。
