Human Clinical Research Facility, Exercise & Sport Nutrition Lab, Department of Health & Kinesiology, Texas A&M University, College Station, TX 77843, USA.
Physiology of Work and Exercise Response (POWER) Laboratory, Institute of Exercise Physiology and Rehabilitation Science, School of Kinesiology and Physical Therapy, University of Central Florida, 12494 University Blvd., Orlando, FL 32816, USA.
Nutrients. 2021 Jan 29;13(2):447. doi: 10.3390/nu13020447.
Although creatine has been mostly studied as an ergogenic aid for exercise, training, and sport, several health and potential therapeutic benefits have been reported. This is because creatine plays a critical role in cellular metabolism, particularly during metabolically stressed states, and limitations in the ability to transport and/or store creatine can impair metabolism. Moreover, increasing availability of creatine in tissue may enhance cellular metabolism and thereby lessen the severity of injury and/or disease conditions, particularly when oxygen availability is compromised. This systematic review assesses the peer-reviewed scientific and medical evidence related to creatine's role in promoting general health as we age and how creatine supplementation has been used as a nutritional strategy to help individuals recover from injury and/or manage chronic disease. Additionally, it provides reasonable conclusions about the role of creatine on health and disease based on current scientific evidence. Based on this analysis, it can be concluded that creatine supplementation has several health and therapeutic benefits throughout the lifespan.
虽然肌酸主要作为运动、训练和运动的能量增强剂进行研究，但已报道其具有多种健康和潜在的治疗益处。这是因为肌酸在细胞代谢中起着关键作用，特别是在代谢应激状态下，并且运输和/或储存肌酸的能力有限会损害代谢。此外，组织中肌酸的可用性增加可能会增强细胞代谢，从而减轻损伤和/或疾病的严重程度，特别是在氧气供应受到损害时。本系统评价评估了与肌酸在促进衰老过程中的整体健康中的作用相关的经过同行评审的科学和医学证据，以及肌酸补充如何被用作营养策略来帮助个体从损伤中恢复和/或管理慢性疾病。此外，它根据当前的科学证据对肌酸在健康和疾病中的作用提供了合理的结论。基于此分析，可以得出结论，肌酸补充剂在整个生命周期中具有多种健康和治疗益处。
