Else K J, Wakelin D, Wassom D L, Hauda K M
Department of Zoology, Nottingham University, UK.
Parasitology. 1990 Aug;101 Pt 1:61-7. doi: 10.1017/s0031182000079762.
Two panels of H-2 recombinant strains of mice were used in an attempt to map the H-2-linked genes which control resistance to infection with Trichuris muris. Response phenotypes could be related to the presence of 'resistance' (q,b) or 'susceptibility' (k,d) alleles at I-A. The influence of these genes was modulated by other alleles, particularly q or d alleles, at the D end of the H-2. Absence of I-E molecules correlated with resistance to infection in some but not all strains studied. Thus the (B10.BR x B10.G) F1 strain which expressed I-Ek gene products was resistant to infection. A study of the time-course of infection in strains of mice expressing q alleles throughout the H-2 on 4 different genetic backgrounds (NIH, SWR, DBA and B10) revealed that most strains were resistant to infection. However, the DBA/1 strain exhibited differential responsiveness, 4 out of 6 individuals harbouring mature adult parasites on day 35 post-infection.
使用两组H-2重组小鼠品系试图定位与控制对鼠鞭虫感染抵抗力相关的H-2连锁基因。反应表型可能与I-A位点上“抗性”（q，b）或“易感性”（k，d）等位基因的存在有关。这些基因的影响受到H-2 D端其他等位基因的调节，特别是q或d等位基因。在一些但不是所有研究的品系中，I-E分子的缺失与感染抵抗力相关。因此，表达I-Ek基因产物的（B10.BR×B10.G）F1品系对感染具有抗性。对在4种不同遗传背景（NIH、SWR、DBA和B10）下整个H-2上都表达q等位基因的小鼠品系感染的时间进程研究表明，大多数品系对感染具有抗性。然而，DBA/1品系表现出不同的反应性，6只中有4只在感染后第35天携带成熟成虫寄生虫。
