Else K, Wakelin D
Department of Zoology, University of Nottingham.
Parasitology. 1988 Jun;96 ( Pt 3):543-50. doi: 10.1017/s0031182000080173.
Two groups of H-2 congenic strains of mice were compared for their susceptibility to a primary infection with the nematode Trichuris muris. Mice of the BALB genetic background were markedly more resistant than mice of the B10 genetic background, as reflected by the rate of expulsion of T. muris from the large intestine. Within each of the two groups of H-2 congenic strains mice possessing the H-2k haplotype (BALB/k, B10.BR) were more susceptible to infection than mice expressing other haplotypes; B10 background strains expressing H-2b (B10) or H-2q (B10.G) alleles were the most resistant of the four congenic strains studied. Differential resistance was observed within three of the four B10 congenic strains and this is discussed in terms of rate of development of the protective immune response in relation to worm development. The results support the conclusion that both H-2-linked and non-H-2 genes play important roles in controlling the immune response which expels worms from the gut.
比较了两组H-2同类系小鼠对线虫毛首鞭形线虫初次感染的易感性。BALB遗传背景的小鼠比B10遗传背景的小鼠具有明显更高的抵抗力，这可通过从大肠中排出毛首鞭形线虫的速率反映出来。在两组H-2同类系小鼠中，具有H-2k单倍型（BALB/k、B10.BR）的小鼠比表达其他单倍型的小鼠更易感染；表达H-2b（B10）或H-2q（B10.G）等位基因的B10背景品系是所研究的四个同类系中抵抗力最强的。在四个B10同类系中的三个中观察到了差异抗性，并根据保护性免疫反应相对于蠕虫发育的发育速率进行了讨论。结果支持这样的结论，即H-2连锁基因和非H-2基因在控制从肠道排出蠕虫的免疫反应中都起重要作用。
