《所有战斗之母 20 年后：LTP 是在突触前还是突触后表达？》
The Mother of All Battles 20 years on: is LTP expressed pre- or postsynaptically?
机构信息
UCL Institute of Neurology, University College London, London WC1N 3BG, UK.
出版信息
J Physiol. 2012 May 15;590(10):2213-6. doi: 10.1113/jphysiol.2011.221127. Epub 2012 Feb 20.
Abstract
The early 1990s saw an intense debate over the locus of expression of NMDA receptor-dependent LTP. This provided an impetus for intense research into the mechanisms of modulation and trafficking of glutamate receptors and presynaptic vesicles. As new forms of LTP are discovered at different synapses, a simple resolution of the pre- versus postsynaptic debate seems increasingly remote.
摘要
上世纪 90 年代早期，人们围绕 NMDA 受体依赖性 LTP 的表达位置展开了激烈的辩论。这促使人们深入研究谷氨酸受体和突触前小泡的调节和运输机制。随着在不同突触发现新的 LTP 形式，突触前与突触后争论的简单解决方案似乎越来越遥远。
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