红茶多酚抑制肿瘤蛋白酶体活性。
Black tea polyphenols inhibit tumor proteasome activity.
机构信息
The Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute and Department of Oncology, School of Medicine, Wayne State University, Detroit, MI 48201-2013, USA.
出版信息
In Vivo. 2012 Mar-Apr;26(2):197-202.
Abstract
Tea is a widely consumed beverage and its constituent polyphenols have been associated with potential health benefits. Although black tea polyphenols have been reported to possess potent anticancer activities, the effect of its polyphenols, theaflavins on the tumor's cellular proteasome function, an important biological target in cancer prevention, has not been carefully studied. Here black tea extract (T5550) enriched in theaflavins inhibited the chymotrypsin-like (CT) activity of the proteasome and proliferation of human multiple myeloma cells in a dose-dependent manner. Also an isolated theaflavin (TF-1) can bind to, and inhibit the purified 20S proteasome, accompanied by suppression of tumor cell proliferation, suggesting that the tumor proteasome is an important target whose inhibition is at least partially responsible for the anticancer effects of black tea.
摘要
茶是一种广泛饮用的饮料，其所含的多酚类化合物与潜在的健康益处有关。虽然已经报道红茶多酚具有很强的抗癌活性，但它的多酚类化合物——茶黄素对肿瘤细胞蛋白酶体功能的影响，作为癌症预防的一个重要生物靶点，尚未得到仔细研究。本研究中，富含茶黄素的红茶提取物（T5550）可剂量依赖性抑制蛋白酶体的糜蛋白酶样（CT）活性和人多发性骨髓瘤细胞的增殖。此外，一种分离的茶黄素（TF-1）可以与纯化的 20S 蛋白酶体结合并抑制其活性，同时抑制肿瘤细胞增殖，这表明肿瘤蛋白酶体是一个重要的靶点，其抑制作用至少部分解释了红茶的抗癌作用。
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