Topcu Alpaslan, Aydin Osman E, Ünlü Mehtat, Barutcu Ali, Atabey Atay
Alpaslan Topcu Aesthetic and Plastic Surgery Clinic, Istanbul, Turkey.
Arch Facial Plast Surg. 2012 Jul-Aug;14(4):270-6. doi: 10.1001/archfacial.2011.1633.
To increase the viability of fat grafts using vascular endothelial growth factor (VEGF) in a calcium alginate microsphere controlled release system.
Twenty-four rats were divided into 4 groups of 6 rats each. Group 1 was the preconditioning group in which VEGF was applied prior to the fat grafting. In group 2,VEGF was given at the time of the grafting. In group 3, an empty microsphere was added to the grafting material. The fourth group, which received the fat graft only, was the control group. At the 90th day, samples of the fat grafts were weighed and compared with preimplantation weights.
The graft viability ratios of the first 3 groups were significantly higher than those of the control group. The relative adipocyte index was significantly higher in the first and second groups compared with the control group and group 3. Consistent with the literature, VEGF used both in the preconditioning procedure and simultaneously with the grafting procedure increased the graft viability ratio and relative adipocyte index.
This study suggests that VEGF-induced preconditioning of the recipient bed improves fat graft viability via increased revascularization.
在海藻酸钙微球控释系统中使用血管内皮生长因子（VEGF）提高脂肪移植的存活率。
将24只大鼠分为4组，每组6只。第1组为预处理组，在脂肪移植前应用VEGF。第2组在移植时给予VEGF。第3组在移植材料中添加空微球。仅接受脂肪移植的第四组为对照组。在第90天，对脂肪移植样本称重并与植入前重量进行比较。
前三组的移植存活率显著高于对照组。与对照组和第3组相比，第一组和第二组的相对脂肪细胞指数显著更高。与文献一致，在预处理过程中以及与移植过程同时使用VEGF可提高移植存活率和相对脂肪细胞指数。
本研究表明，VEGF诱导的受体床预处理通过增加血管再生提高了脂肪移植的存活率。
