National Center for Medical Rehabilitation Research, Eunice Kennedy Shriver Institute of Child Health and Human Development, Bethesda, Maryland, United States.
Langmuir. 2012 Mar 13;28(10):4723-8. doi: 10.1021/la204317k. Epub 2012 Feb 28.
X-ray and neutron diffraction studies of a binary lipid membrane demonstrate that halothane at physiological concentrations produces a pronounced redistribution of lipids between domains of different lipid types identified by different lamellar d-spacings and isotope composition. In contrast, dichlorohexafluorocyclobutane (F6), a halogenated nonanesthetic, does not produce such significant effects. These findings demonstrate a specific effect of inhalational anesthetics on mixing phase equilibria of a lipid mixture.
X 射线和中子衍射研究表明，在生理浓度下，氟烷会导致脂质在不同类型的脂质域之间明显重新分布，这些域通过不同的层间距和同位素组成来识别。相比之下，六氟二氯环丁烷（F6），一种卤代非麻醉剂，不会产生如此显著的影响。这些发现表明吸入麻醉剂对脂质混合物混合相平衡具有特定的影响。
