Department de Química Física and Institut de Química Teòrica i Computacional (IQTCUB), Universitat de Barcelona, c/ Martí i Franqués 1, Pta 4, 08028 Barcelona Spain.
Sci Rep. 2016 Sep 6;6:32934. doi: 10.1038/srep32934.
The spatial coincidence of lipid domains at both layers of the cell membrane is expected to play an important role in many cellular functions. Competition between the surface interleaflet tension and a line hydrophobic mismatch penalty are conjectured to determine the transversal behavior of laterally heterogeneous lipid membranes. Here, by a combination of molecular dynamics simulations, a continuum field theory and kinetic equations, I demonstrate that the presence of small, rapidly translocating molecules residing in the lipid bilayer may alter its transversal behavior by favoring the spatial coincidence of similar lipid phases.
细胞膜的两层中脂域的空间重合预计在许多细胞功能中发挥重要作用。推测表面层间张力与线疏水失配罚分之间的竞争决定了横向异质脂膜的横向行为。在这里，通过分子动力学模拟、连续场理论和动力学方程的组合，我证明了小的、快速迁移的分子存在于脂质双层中可能通过有利于类似脂质相的空间重合来改变其横向行为。
