Division of Cell Signaling and Immunology, College of Life Sciences, University of Dundee, United Kingdom.
Ann N Y Acad Sci. 2012 Apr;1253:102-11. doi: 10.1111/j.1749-6632.2011.06449.x. Epub 2012 Feb 21.
The immune system must be tightly regulated to prevent unwanted tissue damage caused by exaggerated immune and inflammatory reactions. Inhibitory and activating immune receptors play a crucial role in this function via phosphotyrosine-dependent signaling pathways. A significant body of evidence has accumulated suggesting that the siglec family of sialic acid binding Ig-like lectins makes an important contribution to this immunoregulation. The CD33-related siglecs are a distinct subset of inhibitory and activating receptors, expressed primarily on leukocytes in a cell type-specific manner. Here, we critically assess the in vitro and in vivo evidence on the functional role for CD33-related siglecs in modulation of inflammatory and immune responses.
免疫系统必须受到严格的调节，以防止过度的免疫和炎症反应引起的组织损伤。抑制性和激活性免疫受体通过磷酸酪氨酸依赖性信号通路在这一功能中发挥着至关重要的作用。大量证据表明，唾液酸结合免疫球蛋白样凝集素家族的 siglec 对这种免疫调节有重要贡献。CD33 相关的 siglecs 是抑制性和激活性受体的一个独特子集，主要以细胞类型特异性的方式在白细胞上表达。在这里，我们批判性地评估了 CD33 相关 siglecs 在调节炎症和免疫反应中的功能作用的体外和体内证据。
