Ronald O Perelman Department of Dermatology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.
Dermatol Ther. 2011 Sep-Oct;24(5):464-70. doi: 10.1111/j.1529-8019.2012.01460.x.
The development of topical drug delivery systems has recently gained significant interest due to the ease of administration and lesser risks of systemic toxicity. The development of these new technologies utilizes the properties of the structure and function of the skin. The stratum corneum plays the largest role in affecting drug permeation, as the corneocytes and lipid matrix in this layer effectively prevent the diffusion of large molecules. In this review, we introduce the structure and function of the skin as it relates to topical drug delivery.
由于给药方便和全身毒性风险较低，局部药物递送系统的发展最近引起了极大的关注。这些新技术的开发利用了皮肤结构和功能的特性。角质层在影响药物渗透方面起着最大的作用，因为该层中的角质细胞和脂质基质有效地阻止了大分子的扩散。在这篇综述中，我们介绍了与局部药物递送相关的皮肤结构和功能。
