Departments of Medicine and Pathology, National University Hospital, Singapore.
Dermatol Ther. 2011 Sep-Oct;24(5):505-7. doi: 10.1111/j.1529-8019.2012.01474.x.
An extensive range of diseases or reactions can cause pustular eruptions of the skin. Drug-provoked cutaneous eruptions includes acute generalized exanthematous pustulosis (AGEP) and acneiform eruption. We report a 50-year-old man who developed fever and a sudden eruption of widespread pustules 12 days after ingestion of celecoxib prescribed for a prolapsed intervertebral disc. AGEP was diagnosed based on the typical history, characteristic features, and laboratory findings. However, histopathological findings were consistent with folliculitic drug reaction pattern without features of AGEP. We present, the first known reported case of folliculitic drug reaction pattern caused by celecoxib.
广泛的疾病或反应都可能导致皮肤出现脓疱。药物引起的皮肤疹包括急性全身性发疹性脓疱病（AGEP）和痤疮样疹。我们报告了一例 50 岁男性，在服用塞来昔布治疗椎间盘突出症 12 天后出现发热和广泛脓疱突然发作。根据典型病史、特征和实验室发现诊断为 AGEP。然而，组织病理学发现与无 AGEP 特征的滤泡性药物反应模式一致。我们提出了首例已知的由塞来昔布引起的滤泡性药物反应模式。
