天然倍半萜类化合物作为细胞毒性抗癌剂。

Natural sesquiterpenoids as cytotoxic anticancer agents.

机构信息

Department of Organic Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan, P. R. China.

出版信息

Mini Rev Med Chem. 2011 Nov;11(13):1153-64. doi: 10.2174/138955711797655399.

Abstract

Sesquiterpenoids are a group of naturally occurring 15-carbon isoprenoid compounds that are mainly found in higher plants, microorganism and marine life. Many of them provided encouraging leads for chemotherapeutics. In this review, the sesquiterpenoids are classified according to the ring numbering system and the functional groups presented in the core structures as acyclic, mono-, bi-, and tricyclic derivatives, and a current overview of sesquiterpenoids as potential cytotoxic anticancer agents is provided.

摘要

倍半萜类化合物是一组天然存在的 15 碳异戊二烯化合物，主要存在于高等植物、微生物和海洋生物中。其中许多化合物为化学疗法提供了令人鼓舞的线索。在这篇综述中，根据环编号系统和核心结构中存在的官能团，将倍半萜类化合物分为无环、单环、双环和三环衍生物，并提供了倍半萜类化合物作为潜在细胞毒性抗癌剂的最新概述。