Cellular and Molecular Neuroscience Laboratory, National Brain Research Centre, Manesar, Gurgaon-122050, India.
Neurochem Int. 2012 Apr;60(5):443-7. doi: 10.1016/j.neuint.2012.02.009. Epub 2012 Feb 15.
Protein homeostasis is fundamental in normal cellular function and cell survival. The ubiquitin-proteasome system (UPS) plays a central role in maintaining the protein homeostasis network through selective elimination of misfolded and damaged proteins. Impaired function of UPS is implicated in normal aging process and also in several age-related neurodegenerative disorders that are characterized by increased accumulation oxidatively modified proteins and protein aggregates. Growing literature also indicate the potential role of various ubiquitin protein ligases in the regulation of aging process by enhancing the degradation of either central lifespan regulators or abnormally folded and damaged proteins. This review mainly focuses on our current understanding of the importance of UPS function in the regulation of normal aging process.
蛋白质内稳性是正常细胞功能和细胞存活的基础。泛素-蛋白酶体系统（UPS）通过选择性清除错误折叠和受损的蛋白质，在维持蛋白质内稳性网络中发挥核心作用。UPS 功能受损与正常衰老过程以及几种与年龄相关的神经退行性疾病有关，这些疾病的特征是氧化修饰蛋白和蛋白质聚集体的积累增加。越来越多的文献也表明，各种泛素蛋白连接酶通过增强中央寿命调节剂或异常折叠和受损蛋白质的降解，在调节衰老过程中可能发挥作用。本综述主要集中于我们目前对 UPS 功能在正常衰老过程调节中的重要性的理解。
