耐甲氧西林金黄色葡萄球菌、金黄色葡萄球菌、铜绿假单胞菌和大肠杆菌的多次传代研究中，对 NVC-422 的敏感性没有降低。
No decrease in susceptibility to NVC-422 in multiple-passage studies with methicillin-resistant Staphylococcus aureus, S. aureus, Pseudomonas aeruginosa, and Escherichia coli.
机构信息
NovaBay Pharmaceuticals, Inc, Emeryville, California, USA..
出版信息
Antimicrob Agents Chemother. 2012 May;56(5):2753-5. doi: 10.1128/AAC.05985-11. Epub 2012 Feb 21.
Abstract
Twenty-five serial passages of Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus and 50 passages of methicillin-resistant Staphylococcus aureus resulted in no significant increase in NVC-422 MICs, while ciprofloxacin MICs increased 256-fold for E. coli and 32-fold for P. aeruginosa and S. aureus. Mupirocin, fusidic acid, and retapamulin MICs for MRSA increased 64-, 256-, and 16-fold, respectively. No cross-resistance to NVC-422 was observed with mupirocin-, fusidic acid-, and retapamulin-resistant strains.
摘要
25 株连续传代的大肠杆菌、铜绿假单胞菌和金黄色葡萄球菌和 50 株连续传代的耐甲氧西林金黄色葡萄球菌导致 NVC-422 的 MIC 没有显著增加，而环丙沙星对大肠杆菌和铜绿假单胞菌及金黄色葡萄球菌的 MIC 增加了 256 倍和 32 倍。耐甲氧西林金黄色葡萄球菌的莫匹罗星、夫西地酸和瑞他帕林的 MIC 分别增加了 64 倍、256 倍和 16 倍。对莫匹罗星、夫西地酸和瑞他帕林耐药的菌株对 NVC-422 没有交叉耐药性。
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