抗莫匹罗星耐药性耐甲氧西林金黄色葡萄球菌儿科分离株的瑞他帕林活性。
Retapamulin Activity Against Pediatric Strains of Mupirocin-resistant Methicillin-resistant Staphylococcus aureus.
机构信息
From the Department of Pediatrics, Division of Pediatric Infectious Diseases.
Department of Infection Prevention and Control.
出版信息
Pediatr Infect Dis J. 2021 Jul 1;40(7):637-638. doi: 10.1097/INF.0000000000003123.
Retapamulin activity against 53 isolates obtained from a mupirocin-resistant community-acquired methicillin-resistant Staphylococcus aureus pediatric disease cluster was evaluated using broth microdilution. All strains were susceptible to retapamulin with minimum inhibitory concentrations ≤ 0.5 μg/mL. DNA sequence analysis of rplC and cfr identified one rplC strain variant that did not demonstrate reduced phenotypic susceptibility to retapamulin. These results demonstrate that retapamulin may be a useful alternative therapy for mupirocin-resistant community-acquired methicillin-resistant S. aureus, especially in disease clusters.
使用肉汤微量稀释法评估了从一个社区获得性耐甲氧西林金黄色葡萄球菌（MRSA）儿童疾病群中获得的 53 株耐莫匹罗星的分离株对瑞他帕林的活性。所有菌株对瑞他帕林均敏感，最小抑菌浓度（MIC）≤0.5μg/ml。rplC 和 cfr 的 DNA 序列分析鉴定出一种 rplC 株变异体，其对瑞他帕林的表型敏感性没有降低。这些结果表明，瑞他帕林可能是一种对抗耐莫匹罗星的社区获得性耐甲氧西林金黄色葡萄球菌的有效替代疗法，尤其是在疾病群中。
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