中国鸭和鹅中分离到的新型黄病毒——鸭坦布苏病毒的全基因组序列。
Complete genome sequence of a novel flavivirus, duck tembusu virus, isolated from ducks and geese in china.
机构信息
Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.
出版信息
J Virol. 2012 Mar;86(6):3406-7. doi: 10.1128/JVI.07132-11.
Abstract
Duck tembusu virus (DTMUV) is an emerging agent that causes a severe disease in ducks. We report herein the first complete genome sequences of duck tembusu virus strains YY5, ZJ-407, and GH-2, isolated from Shaoxing ducks, breeder ducks, and geese, respectively, in China. The genomes of YY5, ZJ-407, and GH-2 are all 10,990 nucleotides (nt) in length and encode a putative polyprotein of 3,426 amino acids. It is flanked by a 5' and a 3' noncoding region (NCR) of 94 and 618 nt, respectively. Knowledge of the whole sequence of DTMUV will be useful for further studies of the mechanisms of virus replication and pathogenesis.
摘要
鸭坦布苏病毒（DTMUV）是一种新兴的病原体，可导致鸭子发生严重疾病。我们在此报告了从中国绍兴鸭、种鸭和鹅中分别分离到的鸭坦布苏病毒株 YY5、ZJ-407 和 GH-2 的完整基因组序列。YY5、ZJ-407 和 GH-2 的基因组均长 10990 个核苷酸（nt），编码一个推定的 3426 个氨基酸的多蛋白。其两端为 5' 和 3' 非编码区（NCR），分别长 94 和 618 nt。了解 DTMUV 的全序列将有助于进一步研究病毒复制和发病机制。
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