中国人群中基因多态性与妊娠期糖尿病易感性的关联
Association between gene polymorphisms and gestational diabetes mellitus susceptibility in a Chinese population.
作者信息
Wu Yanying, Zhang Yuxuan, Liu Xin, Liu Jia, He Zhaotao, Wei Yue, Zeng Qiaoli, Guo Runmin
机构信息
Department of Internal Medicine, Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, Guangdong, China.
Key Laboratory of Research in Maternal and Child Medicine and Birth Defects, Guangdong Medical University, Foshan, Guangdong, China.
出版信息
Front Endocrinol (Lausanne). 2025 Jul 2;16:1451942. doi: 10.3389/fendo.2025.1451942. eCollection 2025.
INTRODUCTION
The potassium voltage-gated channel subfamily Q member 1 () gene is recognized as a type 2 diabetes mellitus (T2DM) susceptibility gene. However, there is limited data regarding the association between KCNQ1 gene polymorphisms and gestational diabetes mellitus (GDM) susceptibility in China. To explore the association between gene polymorphisms and GDM susceptibility in a Chinese population.
METHODS
We conducted a case-control study including 500 pregnant women with GDM and 502 pregnant women with normal glucose tolerance (as controls). Blood samples and clinical data were collected. gene rs2237897, rs163184, rs151290, and rs2237892 were genotyped by SNPscan™ genotyping assay. Using SPSS V.26.0, statistical analysis was performed to explore the association of gene polymorphisms with GDM and genotypes with blood glucose levels. Meta-analysis was further validated in different populations.
RESULTS
After being adjusted for confounding factors (age, parity, pre-pregnancy BMI (pre-BMI) and blood pressure) and Bonferroni correction, rs2237897 showed an association with decreased GDM risk in codominant heterozygous (CT vs. CC: OR = 0.537; 95% CI: 0.354-0.816; = 0.004) and overdominant models (CT vs. CC+TT: OR = 0.533; 95% CI: 0.355-0.801; = 0.002) in pregnant women aged < 30 years. However, rs2237892, rs151290, and rs163184 did not found associations with GDM after Bonferroni correction. Meta-analysis showed that rs2237892 was associated with decreased GDM risk in different races in dominant (TC+TT vs. CC: OR = 0.830; 95% CI: 0.699-0.985; = 0.033), recessive (TT vs. CT+CC: OR = 0.733; 95% CI: 0.612-0.877; = 0.001), codominant homozygous (TT vs. CC: OR = 0.679; 95% CI: 0.562-0.820; < 0.001), codominant heterozygous (TC vs. CC: OR = 0.843; 95% CI: 0.753-0.945; = 0.003) and allele models (T vs. C: OR = 0.852; 95% CI: 0.740-0.982; = 0.027).
CONCLUSION
rs2237897 is associated with decreased GDM risk in a Chinese population. Although rs2237892 did not found association with GDM risk in our subjects, meta-analysis confirmed that rs2237892 is associated with reduced GDM risk across different populations. Further studies are needed to confirm these findings and elucidate the mechanisms.
引言
钾离子电压门控通道Q亚家族成员1（KCNQ1）基因被认为是2型糖尿病（T2DM）的易感基因。然而，在中国，关于KCNQ1基因多态性与妊娠期糖尿病（GDM）易感性之间关联的数据有限。本研究旨在探讨中国人群中KCNQ1基因多态性与GDM易感性之间的关联。
方法
我们进行了一项病例对照研究，纳入500例GDM孕妇和502例糖耐量正常的孕妇（作为对照）。收集血样和临床资料。采用SNPscan™基因分型检测法对KCNQ1基因的rs2237897、rs163184、rs151290和rs2237892进行基因分型。使用SPSS V.26.0软件进行统计分析，以探讨KCNQ1基因多态性与GDM的关联以及基因分型与血糖水平的关系。并在不同人群中进行荟萃分析以进一步验证。
结果
在对混杂因素（年龄、产次、孕前体重指数（pre-BMI）和血压）进行校正并经Bonferroni校正后，rs2237897在年龄<30岁的孕妇中，共显性杂合模型（CT vs. CC：OR = 0.537；95%CI：0.354 - 0.816；P = 0.004）和超显性模型（CT vs. CC + TT：OR = 0.533；95%CI：0.355 - 0.801；P = 0.002）中显示与GDM风险降低相关。然而，经Bonferroni校正后，rs2237892、rs151290和rs163184未发现与GDM有关联。荟萃分析显示，rs2237892在不同种族中，显性模型（TC + TT vs. CC：OR = 0.830；95%CI：0.699 - 0.985；P = 0.033）、隐性模型（TT vs. CT + CC：OR = 0.733；95%CI：0.612 - 0.877；P = 0.001）、共显性纯合模型（TT vs. CC：OR = 0.679；95%CI：0.562 - 0.820；P < 0.001）、共显性杂合模型（TC vs. CC：OR = 0.843；95%CI：0.753 - 0.945；P = 0.003）和等位基因模型（T vs. C：OR = 0.852；95%CI：0.740 - 0.982；P = 0.027）中均与GDM风险降低相关。
结论
rs2237897与中国人群中GDM风险降低相关。虽然在本研究对象中rs2237892未发现与GDM风险有关联，但荟萃分析证实rs2237892在不同人群中均与GDM风险降低相关。需要进一步研究来证实这些发现并阐明其机制。
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