Abbass F, Bennis S, Znati K, Akasbi Y, Amrani J K, El Mesbahi O, Amarti A
Faculté des Sciences et Techniques de Fès, Fès, Maroc.
East Mediterr Health J. 2011 Dec;17(12):930-6.
In a retrospective study of 265 patients with breast cancer over 3 years (January 2007-September 2009) we examined the epidemiological profile of breast cancer to determine the impact of biological and prognostic factors on survival over 3 years and on the epidemiology of this cancer. Estrogen (RE), progesterone (RP) and human epidermal growth factor receptors (HER2) were evaluated and RE/RP/HER2 status determined. The patients were young (median age 45 years). Invasive tumours were found in 95.5% of the women. The average tumour size was big [3.6 (SD 2.6) cm] and only 14% were histological grade 1. Large tumour size and high histological grade were independent of patient's age. Overall survival at 3 years was only 49% for the RE-/RP-/HER2- subtype and 75% for the RE-/RP-/HER2+ subtype, while it was 96% for the RE+/RP+/HER2- subtype. The young age, large tumour size and high histological grade in our population suggest a lack of awareness of women about breast cancer.
在一项对265例乳腺癌患者进行的为期3年（2007年1月至2009年9月）的回顾性研究中，我们调查了乳腺癌的流行病学特征，以确定生物学和预后因素对3年生存率以及对这种癌症流行病学的影响。评估了雌激素（RE）、孕激素（RP）和人表皮生长因子受体（HER2），并确定了RE/RP/HER2状态。患者较为年轻（中位年龄45岁）。95.5%的女性发现有浸润性肿瘤。平均肿瘤大小较大[3.6（标准差2.6）厘米]，只有14%为组织学1级。肿瘤大小和组织学分级高与患者年龄无关。RE-/RP-/HER2-亚型3年总生存率仅为49%，RE-/RP-/HER2+亚型为75%，而RE+/RP+/HER2-亚型为96%。我们研究人群中的年轻、肿瘤大小大和组织学分级高表明女性对乳腺癌缺乏认识。
