Laboratory of Genetic, Neuro-Endocrinology and Biotechnology, Ibn Tofail University, Kenitra, Morocco.
Oncology-Radiotherapy, Mohammed VI Cancer Treatment Center, Ibn Rochd University Hospital, Casablanca, Morocco.
Pan Afr Med J. 2020 Dec 15;37:343. doi: 10.11604/pamj.2020.37.343.23004. eCollection 2020.
Male breast cancer is a rare disease accounting for less than 1% of all breast cancer diagnoses worldwide to our knowledge. The aim of this retrospective study is to analyse the epidemiologic, clinical, therapeutic and evolutive profiles of this disease and to compare some cancer aspects between male and female in 25 cases collected at Mohamed VI Oncology Center at the University Hospital of Casablanca between 2012 and 2018. Of all breast cancers, men with breast cancer make up a minority. Male compared to female breast cancers occurred later in life with higher stage and more estrogen receptor-positive tumors. The median age was 67.7 years. The average diagnosis delay was 15.7 month. Cancer was discovered through self examination in 76.1% of cases. The mean diameter was 3.5 cm and range from 1-6 cm. According to the tumor-node-metastasis (TNM) classification, tumors were classified as T1-T2 (40%) and T3-T4 (60%). Infiltrating ductal carcinoma was the most frequent (92%) and 1 case of lobular carcinoma. Axillary nodal involvement was present in 82.4% of cases. Hormonal receptors were positive in 83% of cases. 86.6% of our cases present metastasis. Bone was the most representative site. Surgery was usually mastectomy with axillary clearance. It was possible to follow 21 of the patients. The median of follow-up was 12 months. The evolution has been characterized by local recurrence in 6 cases. There was 9 cases of death. Death was usually due to comorbid disease and to the advanced age. The 5 years overall survival rates were 57%.
据我们所知，男性乳腺癌是一种罕见疾病，占全球所有乳腺癌诊断的比例不到 1%。本回顾性研究的目的是分析这种疾病的流行病学、临床、治疗和演变特征，并在 2012 年至 2018 年期间在卡萨布兰卡大学医院莫哈默德六世肿瘤中心收集的 25 例病例中比较男性和女性的一些癌症方面。在所有乳腺癌中，男性乳腺癌占少数。与女性乳腺癌相比，男性乳腺癌发病年龄较晚，分期较高，雌激素受体阳性肿瘤较多。中位年龄为 67.7 岁。平均诊断延迟为 15.7 个月。76.1%的病例是通过自我检查发现癌症的。平均直径为 3.5 厘米，范围为 1-6 厘米。根据肿瘤-淋巴结-转移（TNM）分类，肿瘤分为 T1-T2（40%）和 T3-T4（60%）。浸润性导管癌最常见（92%），1 例为小叶癌。82.4%的病例存在腋窝淋巴结受累。激素受体阳性率为 83%。我们的病例中有 86.6%存在转移。骨是最具代表性的部位。手术通常是乳房切除术和腋窝清扫术。可以随访 21 例患者。中位随访时间为 12 个月。疾病的演变特征是 6 例局部复发，9 例死亡。死亡通常是由于合并疾病和高龄。5 年总生存率为 57%。
