Harvey Louise, Knowles Toby, Murison Pamela J
School of Clinical Veterinary Science, University of Bristol, Langford House, Langford, Bristol, UK.
Vet Anaesth Analg. 2012 Mar;39(2):174-84. doi: 10.1111/j.1467-2995.2011.00685.x.
To measure the level of agreement between Doppler measured (DOP) arterial blood pressure (ABP) in the forelimb and directly measured (DIR) auricular systolic ABP (SAP) and mean ABP (MAP) in isoflurane-anaesthetized rabbits.
Prospective clinical study.
Data were analysed from 17 of 24 healthy rabbits, weighing 1.3-2.8 kg.
Rabbits were anaesthetized for neutering using a standardized protocol. A 26G catheter placed in an auricular artery was connected via heparinised saline filled non-compliant tubing (regularly flushed) to a calibrated pressure transducer (zeroed level with the thoracic inlet) to obtain DIR ABP. A cuff was placed proximal to the carpus (approximately level with the thoracic inlet) and a Doppler transducer sited over the dorsal carpal branch of the radial artery to obtain DOP ABP. Simultaneous DIR and DOP ABP recordings were made every 5-10 minutes during anaesthesia. Agreement was assessed as described by Bland JM & Altman (2007).
Mean ± SD cuff width: limb circumference ratio was 0.50 ± 0.04. Mean between-method differences ± SD, DIR SAP- DOP and DIR MAP- DOP, were +1 ± 8 and -13 ± 8 mmHg respectively. The 95% limits of agreement between DIR SAP and DOP and between DIR MAP and DOP were -14 to +17 and -28 to +2 mmHg respectively. Differences between DIR SAP and DOP were ≤ 10 mmHg 85% of the time. Defining hypotension as either DIR SAP < 80 mmHg or DIR MAP < 60 mmHg, and taking DOP ABP of <80 mmHg to indicate hypotension, sensitivity and specificity were 92% and 67% respectively.
Good agreement was found between DIR SAP and DOP. Doppler measurements below 80 mmHg are a reliable indicator of arterial hypotension.
DOP is acceptable for monitoring ABP in isoflurane-anaesthetized rabbits and is useful for detection of hypotension.
测量异氟烷麻醉兔前肢经多普勒测量（DOP）的动脉血压（ABP）与直接测量（DIR）的耳收缩期ABP（SAP）和平均ABP（MAP）之间的一致性水平。
前瞻性临床研究。
对24只体重1.3 - 2.8千克的健康兔中的17只的数据进行分析。
采用标准化方案对兔进行麻醉以实施去势手术。将一根26G导管置于耳动脉，通过充满肝素化盐水的非顺应性管道（定期冲洗）连接到校准的压力传感器（零点与胸廓入口平齐）以获取DIR ABP。在腕关节近端（大致与胸廓入口平齐）放置一个袖带，并将一个多普勒传感器置于桡动脉腕背支上方以获取DOP ABP。在麻醉期间每5 - 10分钟同时记录DIR和DOP ABP。按照Bland JM和Altman（2007年）所述评估一致性。
袖带宽度与肢体周长的平均±标准差比值为0.50±0.04。方法间平均差异±标准差，DIR SAP - DOP和DIR MAP - DOP分别为+1±8和 - 13±8 mmHg。DIR SAP与DOP之间以及DIR MAP与DOP之间的95%一致性界限分别为 - 14至+17和 - 28至+2 mmHg。DIR SAP与DOP之间的差异在85%的时间内≤10 mmHg。将低血压定义为DIR SAP < 80 mmHg或DIR MAP < 60 mmHg，并将DOP ABP < 80 mmHg视为低血压，敏感性和特异性分别为92%和67%。
DIR SAP与DOP之间具有良好的一致性。低于80 mmHg的多普勒测量值是动脉低血压的可靠指标。
DOP可用于监测异氟烷麻醉兔的ABP，对低血压检测有用。
