Yin Yibo, Liu Can, Gao Guangjian, Li Jingjing, Long Xuechen, Zhang Peijin, Guo Wenjun
Department of Anesthesia, First Affiliated Hospital of Wannan Medical College, Wuhu, China.
Nuclear Medicine Department, First Affiliated Hospital of Wannan Medical College, Wuhu, China.
Front Pharmacol. 2022 Aug 23;13:890246. doi: 10.3389/fphar.2022.890246. eCollection 2022.
Ephedrine increased blood pressure due to the contractile properties of resistance vessels. Excessive contraction of the uterine arteries might cause fetal distress. This study was to determine the diameter of the uterine artery of female New Zealand rabbits after the administration of different doses of ephedrine using CT.
Thirty-two rabbits were randomly divided into a control group (Group C), low dosage group (Group L), medium dosage group (Group M) and high dosage group (Group H). Normal saline and doses corresponding to the human dose of 7.5, 15 and 30 mg of ephedrine were injected respectively. The marginal ear and uterine artery diameters were measured 5, 10, 15, 30, and 45 min after injection using CT, and the hemodynamic changes were recorded.
The increase in mean arterial pressure in group M (p = 0.009), and H (p = 0.013) was higher than that in group C. Compared with group C, substantial contraction of the marginal ear artery was observed at the three doses of ephedrine. There were no differences in the uterine artery diameter among groups L, M and C, However, in Group H, a significant contraction of the uterine artery compared with the other groups (p < 0.001) was observed.
CT can be used to evaluate the effects of drugs on organs and blood vessels. Ephedrine can not only constrict the peripheral blood vessels but also do not affect the uterine artery at a dose of 15 mg or less. However, the dose should not exceed 30 mg, which may cause severe uterine artery depression.
麻黄碱因阻力血管的收缩特性而使血压升高。子宫动脉过度收缩可能导致胎儿窘迫。本研究旨在使用CT确定不同剂量麻黄碱给药后雌性新西兰兔子宫动脉的直径。
32只兔子随机分为对照组（C组）、低剂量组（L组）、中剂量组（M组）和高剂量组（H组）。分别注射生理盐水以及相当于人类剂量7.5、15和30mg的麻黄碱。注射后5、10、15、30和45分钟使用CT测量边缘耳动脉和子宫动脉直径，并记录血流动力学变化。
M组（p = 0.009）和H组（p = 0.013）的平均动脉压升高高于C组。与C组相比，在三个麻黄碱剂量下均观察到边缘耳动脉明显收缩。L组、M组和C组之间子宫动脉直径无差异，然而，在H组中，观察到与其他组相比子宫动脉有明显收缩（p < 0.001）。
CT可用于评估药物对器官和血管的影响。麻黄碱不仅能收缩外周血管，而且在剂量为15mg或更低时不影响子宫动脉。然而，剂量不应超过30mg，这可能导致严重的子宫动脉收缩。
