Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Am J Clin Nutr. 2012 Apr;95(4):818-24. doi: 10.3945/ajcn.111.027383. Epub 2012 Feb 22.
Epidemiologic evidence shows an increase in obesity concurrent with a reduction in average sleep duration among Americans. Although clinical studies propose that restricted sleep affects hormones related to appetite, neuronal activity in response to food stimuli after restricted and habitual sleep has not been investigated.
The objective of this study was to determine the effects of partial sleep restriction on neuronal activation in response to food stimuli.
Thirty healthy, normal-weight [BMI (in kg/m²): 22-26] men and women were recruited (26 completed) to participate in a 2-phase inpatient crossover study in which they spent either 4 h/night (restricted sleep) or 9 h/night (habitual sleep) in bed. Each phase lasted 6 d, and functional magnetic resonance imaging was performed in the fasted state on day 6.
Overall neuronal activity in response to food stimuli was greater after restricted sleep than after habitual sleep. In addition, a relative increase in brain activity in areas associated with reward, including the putamen, nucleus accumbens, thalamus, insula, and prefrontal cortex in response to food stimuli, was observed.
The findings of this study link restricted sleep and susceptibility to food stimuli and are consistent with the notion that reduced sleep may lead to greater propensity to overeat.
流行病学证据表明，美国人的肥胖率与平均睡眠时间减少呈同步增长。尽管临床研究表明，睡眠受限会影响与食欲相关的激素，但睡眠受限和习惯性睡眠后对食物刺激的神经元反应尚未得到研究。
本研究旨在确定部分睡眠限制对食物刺激反应中神经元激活的影响。
招募了 30 名健康、体重正常的（BMI（kg/m²）：22-26）男性和女性（26 人完成），参与一项 2 期住院交叉研究，他们分别在床上睡 4 小时/晚（限制睡眠）或 9 小时/晚（习惯睡眠）。每个阶段持续 6 天，在第 6 天的禁食状态下进行功能磁共振成像。
与习惯性睡眠相比，限制睡眠后对食物刺激的整体神经元活动更高。此外，观察到与奖励相关的大脑区域（包括纹状体、伏隔核、丘脑、脑岛和前额叶皮层）对食物刺激的反应中，大脑活动相对增加。
本研究的发现将限制睡眠与对食物刺激的敏感性联系起来，这与睡眠减少可能导致过度进食倾向增加的观点一致。
