New York Obesity Research Center, St Luke's-Roosevelt Hospital, New York, NY, USA.
Am J Clin Nutr. 2011 Aug;94(2):410-6. doi: 10.3945/ajcn.111.013904. Epub 2011 Jun 29.
Evidence suggests a relation between short sleep duration and obesity.
We assessed energy balance during periods of short and habitual sleep in normal-weight men and women.
Fifteen men and 15 women aged 30-49 y with a body mass index (in kg/m(2)) of 22-26, who regularly slept 7-9 h/night, were recruited to participate in this crossover inpatient study. All participants were studied under short (4 h/night) and habitual (9 h/night) sleep conditions, in random order, for 5 nights each. Food intake was measured on day 5, and energy expenditure was measured with the doubly labeled water method over each period.
Participants consumed more energy on day 5 during short sleep (2813.6 ± 593.0 kcal) than during habitual sleep (2517.7 ± 593.0 kcal; P = 0.023). This effect was mostly due to increased consumption of fat (20.7 ± 37.4 g; P = 0.01), notably saturated fat (8.7 ± 20.4 g; P = 0.038), during short sleep. Resting metabolic rate (short sleep: 1455.4 ± 129.0 kcal/d; habitual sleep: 1486.5 ± 129.5 kcal/d; P = 0.136) and total energy expenditure (short sleep: 2589.2 ± 526.5 kcal/d; habitual sleep: 2611.1 ± 529.0 kcal/d; P = 0.832) did not differ significantly between sleep phases.
Our data show that a reduction in sleep increases energy and fat intakes, which may explain the associations observed between sleep and obesity. If sustained, as observed, and not compensated by increased energy expenditure, the dietary intakes of individuals undergoing short sleep predispose to obesity. This trial is registered at clinicaltrials.gov as NCT00935402.
有证据表明，睡眠时间短与肥胖之间存在关联。
我们评估了正常体重的男性和女性在短时间和习惯性睡眠时间内的能量平衡。
招募了 15 名年龄在 30-49 岁、体重指数（BMI）为 22-26kg/m2、每晚规律睡眠时间为 7-9h 的男女志愿者参与此项交叉住院研究。所有参与者均按照短时间（4h/晚）和习惯性（9h/晚）睡眠时间的顺序各进行 5 晚的研究。在第 5 天测量食物摄入量，并用双标记水法测量每个时期的能量消耗。
参与者在短时间睡眠（2813.6±593.0kcal）时第 5 天的能量摄入高于习惯性睡眠（2517.7±593.0kcal；P=0.023）。这种影响主要归因于脂肪（20.7±37.4g；P=0.01），特别是饱和脂肪（8.7±20.4g；P=0.038）摄入的增加。在短时间睡眠时，静息代谢率（短时间睡眠：1455.4±129.0kcal/d；习惯性睡眠：1486.5±129.5kcal/d；P=0.136）和总能量消耗（短时间睡眠：2589.2±526.5kcal/d；习惯性睡眠：2611.1±529.0kcal/d；P=0.832）在睡眠阶段之间没有显著差异。
我们的数据表明，睡眠时间的减少会增加能量和脂肪的摄入，这可能解释了睡眠与肥胖之间的关联。如果像观察到的那样持续存在，而不是通过增加能量消耗来补偿，那么经历短时间睡眠的个体的饮食摄入会导致肥胖。这项试验在 clinicaltrials.gov 注册，编号为 NCT00935402。
