Fertility and In-Vitro Fertilization Unit, Department of Obstetrics and Gynecology, Ha'Emek Medical Center, Afula, Israel.
Hum Reprod. 2012 May;27(5):1357-67. doi: 10.1093/humrep/des037. Epub 2012 Feb 21.
Empty follicle syndrome is a condition in which no oocytes are retrieved after an apparently adequate ovarian response to stimulation and meticulous follicular aspiration. It is a rare condition of obscure etiology. A patient with primary infertility who underwent seven assisted reproductive technique cycles is described. In spite of a satisfactory ovarian response, aspiration yielded no oocytes in four cycles and 1-4 low quality oocytes in three cycles. In the index treatment cycle, ovulation was triggered using GnRH agonist 40 h prior to ovum pickup and hCG was added 6 h after the first trigger. Eighteen oocytes were recovered, of which 16 were mature and were inseminated by ICSI. Two embryos were transferred 48 h after aspiration and nine embryos were cryopreserved. The patient conceived and delivered a healthy boy at 38 weeks of gestation. The literature is reviewed and possible etiologies and treatment options of this enigmatic syndrome are suggested.
空卵泡综合征是一种在卵巢对刺激有明显反应且经过细致的卵泡抽吸后仍未能采集到卵母细胞的疾病。其病因不明，较为罕见。本文报道了 1 例原发性不孕患者，该患者接受了 7 个辅助生殖技术周期的治疗。尽管卵巢反应良好，但在 4 个周期中抽吸仅获得 1-4 枚低质量卵母细胞，而在 3 个周期中则未获得卵母细胞。在本次治疗周期中，在取卵前 40 小时使用 GnRH 激动剂触发排卵，并在第一次触发后 6 小时添加 hCG。共回收了 18 个卵母细胞，其中 16 个成熟并通过 ICSI 受精。抽吸后 48 小时移植了 2 个胚胎，9 个胚胎冷冻保存。患者成功妊娠并于 38 孕周分娩 1 名健康男婴。本文对该罕见综合征的可能病因和治疗选择进行了文献复习。
