Department of Ultrastructures, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
Cytotechnology. 1993 Jan;11(Suppl 1):S53-5. doi: 10.1007/BF00746054.
Perturbation of the oxidative balance in biological systems plays an important role in numerous pathological states as well as in many physiological processes such as receptor activity. In order to evaluate if oxidative stress induced by menadione influences membrane receptor processes, a study was conducted on the transferrin receptor. Consequently, biochemical, biophysical and ultrastructural studies were carried out on different cell lines. The results obtained seem to indicate that oxidative stress is able of inducing a rapid and specific down-modulation of membrane transferrin receptor due to a block of receptor recycling on the cell surface without affecting binding affinity.
生物体系氧化平衡的扰乱在众多病理状态以及许多生理过程中都起着重要作用，如受体活性。为了评估甲萘醌诱导的氧化应激是否会影响膜受体过程，我们对转铁蛋白受体进行了研究。因此，我们在不同的细胞系上进行了生化、生物物理和超微结构研究。所得结果似乎表明，氧化应激能够快速且特异性地下调膜转铁蛋白受体，这是由于受体在细胞表面的循环被阻断，而不影响结合亲和力。
