甘露糖赤藓糖醇脂质诱导粒细胞分化并抑制人髓系白血病细胞系 K562 的酪氨酸磷酸化。
Mannosylerythritol lipid induces granulocytic differentiation and inhibits the tyrosine phosphorylation of human myelogenous leukemia cell line K562.
出版信息
Cytotechnology. 1997 Nov;25(1-3):191-5. doi: 10.1023/A:1007982909932.
Abstract
Mannosylerythritol lipid (MEL), which induced granulocytic differentiation of human promyelocytic leukemia cell line HL60, also induced differentiation of human myelogenous leukemia cell line K562. MEL inhibited insulin-dependent cell proliferation and induced leukocyte esterase activity of K562 cells. MEL markedly increased the differentiation-associated characteristics in granulocytes, such as nitroblue tetrazolium (NBT) reducing ability, expression of Fc receptors, and phagocytic activity of K562 cells. The tyrosine phosphorylation in K562 cells inhibited by MEL. These results suggest that MEL directly down-regulates the tyrosine kinase activities in K562 cells to inhibit the cell proliferation and to induce the differentiation.
摘要
甘露糖赤藓糖醇脂质（MEL）可诱导人早幼粒细胞白血病细胞系 HL60 的粒细胞分化，也可诱导人髓系白血病细胞系 K562 的分化。MEL 抑制胰岛素依赖性细胞增殖，并诱导 K562 细胞白细胞酯酶活性。MEL 显著增加粒细胞的分化相关特征，如硝基蓝四唑（NBT）还原能力、Fc 受体表达和 K562 细胞的吞噬活性。MEL 抑制 K562 细胞中的酪氨酸磷酸化。这些结果表明，MEL 通过直接下调 K562 细胞中的酪氨酸激酶活性来抑制细胞增殖并诱导分化。
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