Laboratory of Virology, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy.
Cytotechnology. 1991 Feb;5(Suppl 1):172-5. doi: 10.1007/BF00736841.
The expression of interferon (IFN)-β gene was studied in mouse peritoneal macrophages (PM) harvested from normal mice (lps ( n )) or LPS-hyporesponsive mice (lps ( d )). A strong direct correlation between the LPS response of PM and their capacity to expressing basal levels of IFN was found. The results suggest that the constitutive expression of IFN-β gene can play an important role not only in the resistance to viral infection but also in the modulation of cell differentiation.
本研究旨在探讨正常小鼠（lps（n））和脂多糖低反应性小鼠（lps（d））腹腔巨噬细胞（PM）中干扰素（IFN）-β基因的表达情况。结果发现，PM 对 LPS 的反应与其基础水平 IFN 表达能力之间存在显著的直接相关性。这些结果提示，IFN-β 基因的组成性表达不仅在抗病毒感染的抵抗中起着重要作用，而且在细胞分化的调节中也具有重要意义。
