Das O P, Levi-Minzi S, Koury M, Benner M, Messing J
Waksman Institute, Rutgers, State University of New Jersey, Piscataway 08855-0759.
Proc Natl Acad Sci U S A. 1990 Oct;87(20):7809-13. doi: 10.1073/pnas.87.20.7809.
We have discovered a somatic genomic rearrangement that occurs at high frequency at a duplicated zein locus in certain cultures of the maize inbred line A188. The rearranged allele arises from the duplication by a two-step process involving a homologous recombination and a second event, which may be a deletion, inversion, or insertion; both steps always occur together. The frequency of rearrangement is lower in homozygous states of the parental allele than in heterozygotes. In both cases, the rearrangement is shown to be mitotic. The rearranged product can be transmitted through meiosis, providing another mechanism for genome evolution in higher eukaryotes.
我们在玉米自交系A188的某些培养物中，发现了一种体细胞基因组重排现象，该现象在一个重复的玉米醇溶蛋白基因座处高频发生。重排等位基因由重复序列通过两步过程产生，这两步过程涉及同源重组和第二个事件，第二个事件可能是缺失、倒位或插入；这两个步骤总是同时发生。重排频率在亲本等位基因的纯合状态下比在杂合子中更低。在这两种情况下，重排均显示为有丝分裂。重排产物能够通过减数分裂进行传递，这为高等真核生物的基因组进化提供了另一种机制。
