de Carvalho Carla C C R, Marques Marco P C, Fernandes Pedro
Department of Bioengineering, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, Portugal.
Recent Pat Biotechnol. 2011 Dec;5(3):183-98. doi: 10.2174/187220811797579114.
Iron is the most abundant chemical element on Earth but its most common oxidation state is Fe(III) which presents a very low solubility under physiological conditions. During evolution, micro-organisms have developed sound strategies to acquire iron from both the environment and superior organisms, including direct uptake of iron ions from exogenous iron/heme sources and the synthesis of specialized Fe(III) chelators called siderophores. The present review paper aims at presenting and discussing the latest achievements in siderophore isolation and production, as well as novel applications of these molecules in therapies against iron-related diseases and in vaccines, and their application as antimicrobial agents and biosensors.
铁是地球上含量最丰富的化学元素，但其最常见的氧化态是Fe(III)，在生理条件下其溶解度非常低。在进化过程中，微生物已经开发出了完善的策略，从环境和高等生物中获取铁，包括直接从外源铁/血红素来源摄取铁离子，以及合成称为铁载体的特殊Fe(III)螯合剂。本综述旨在介绍和讨论铁载体分离与生产的最新成果，以及这些分子在治疗铁相关疾病和疫苗中的新应用，及其作为抗菌剂和生物传感器的应用。
