Wang Wenfeng, Qiu Zhiqi, Tan Hongming, Cao Lixiang
School of Environmental Science and Engineering, Sun Yat-sen University, Guangzhou, 510275, People's Republic of China.
Biometals. 2014 Aug;27(4):623-31. doi: 10.1007/s10534-014-9739-2. Epub 2014 Apr 27.
Produced by bacteria, fungi and plants, siderophores are low-molecular-weight chelating agents (200-2,000 Da) to facilitate uptake of iron (Fe). They play an important role in extracellular Fe solubilization from minerals to make it available to microorganisms. Siderophores have various chemical structures and form a family of at least 500 different compounds. Some antibiotics (i.e., albomycins, ferrimycins, danomycins, salmycins, and tetracyclines) can bind Fe and some siderophores showed diverse biological activities. Functions and applications of siderophores derived from actinobacteria were reviewed to better understand the diverse metabolites.
铁载体由细菌、真菌和植物产生，是低分子量螯合剂（200-2000道尔顿），有助于铁（Fe）的摄取。它们在将矿物中的细胞外铁溶解以使其可供微生物利用方面发挥着重要作用。铁载体具有多种化学结构，形成了一个至少包含500种不同化合物的家族。一些抗生素（如白霉素、铁霉素、达诺霉素、沙尔霉素和四环素）可以结合铁，一些铁载体表现出多种生物活性。综述了放线菌来源的铁载体的功能和应用，以更好地了解这些多样的代谢产物。
