Kim Se-Kwon, Ngo Dai-Hung, Vo Thanh-Sang
Department of Chemistry, Pukyong National University, Busan, Republic of Korea.
Adv Food Nutr Res. 2012;65:249-60. doi: 10.1016/B978-0-12-416003-3.00016-0.
Hypertension is the most widespread risk factor for many serious cardiovascular diseases. Angiotensin-converting enzyme (ACE) plays a crucial role in cardiovascular physiological regulation by converting angiotensin I to a potent vasoconstrictor, angiotensin II. Hence, the inhibition of ACE is a key target for antihypertensive activity. Recently, potent antihypertensive peptides have been purified widely by enzymatic hydrolysis of muscle protein, skin collagen, and gelatin of many different kinds of marine fishes. Marine fish-derived bioactive peptides can be developed as antihypertensive components in functional foods or nutraceuticals. This contribution presents an overview of the ACE inhibitory peptides derived from marine fishes and discusses their future prospects to be used as potential drug candidates for preventing and treating high blood pressure.
高血压是许多严重心血管疾病最普遍的风险因素。血管紧张素转换酶（ACE）通过将血管紧张素I转化为强效血管收缩剂血管紧张素II，在心血管生理调节中起关键作用。因此，抑制ACE是抗高血压活性的关键靶点。最近，通过对许多不同种类海鱼的肌肉蛋白、皮肤胶原蛋白和明胶进行酶解，已广泛纯化出强效抗高血压肽。海鱼来源的生物活性肽可开发为功能性食品或营养保健品中的抗高血压成分。本文综述了来源于海鱼的ACE抑制肽，并讨论了它们作为预防和治疗高血压潜在候选药物的未来前景。
