海洋蛋白源血管紧张素转化酶（ACE）抑制肽研究进展

Review on the angiotensin-I-converting enzyme (ACE) inhibitor peptides from marine proteins.

机构信息

School of Biological Science and Technology, Central South University, Changsha 410013, China.

出版信息

Appl Biochem Biotechnol. 2013 Feb;169(3):738-49. doi: 10.1007/s12010-012-0024-y. Epub 2012 Dec 29.

DOI:10.1007/s12010-012-0024-y

Abstract

Hypertension is now a major problem threatening people health in the world. Angiotensin-I-converting enzyme (ACE) plays an important physiological role in regulation of blood pressure via conversion of angiotensin I to angiotensin II. Inhibition of ACE may have an antihypertensive effect as a consequence of a decrease in blood pressure. A number of terrestrial-derived peptides have been reviewed about their in vitro and in vivo ACE-inhibitory activities. Marine organisms are potentially an untapped source of drugs and value-added food production. The aim of this review is to discuss the marine-derived ACE-inhibitory peptides from sources, production, structure aspects, and their future prospects as functional food or novel therapeutic drug candidates.

摘要

高血压现已成为威胁全球人类健康的主要问题。血管紧张素转换酶（ACE）在调节血压方面发挥着重要的生理作用，它可以将血管紧张素 I 转化为血管紧张素 II。ACE 的抑制作用可能会降低血压，从而产生降压效果。已有大量陆生来源的肽类物质的研究报告了它们的体外和体内 ACE 抑制活性。海洋生物是一种有待开发的药物和增值食品的潜在来源。本综述旨在从来源、生产、结构等方面讨论海洋来源的 ACE 抑制肽，并探讨其作为功能性食品或新型治疗药物候选物的未来前景。