Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Sleep Med. 2012 Apr;13(4):396-401. doi: 10.1016/j.sleep.2011.09.017. Epub 2012 Feb 22.
BACKGROUND/OBJECTIVE: The objective of this study was to investigate the differences in hippocampal volume (HV) between narcoleptics and normal controls and determine if HV is associated with memory function in narcoleptics. Left and right HV and intracranial volumes (ICV) were manually measured and compared between two groups.
The study consisted of 36 drug-naïve narcoleptics with cataplexy and 36 age- and sex-matched controls (mean age 29.0 years). All subjects underwent 1.6-mm-thick spoiled gradient recalled magnetic resonance imaging and took the Korean California Verbal Learning Test and the Rey Complex Figure Test to assess verbal and visual memory.
The mean ICV was not different between groups (1599.2 cm(3) in narcoleptics vs. 1623.5 cm(3) in controls, p = .450). Bilateral mean HVs were significantly smaller in narcoleptics (left, 2907.2mm(3) in narcoleptics vs. 3092.3mm(3) in controls, p = 0.005; right, 2990.8mm(3) in narcoleptics vs. 3184.3mm(3) in controls, p = 0.004). Significance of HV differences between groups remained after corrections were made for gender, age, and ICV. In narcoleptics, bilateral HV was positively correlated with mean sleep and REM sleep latencies in Multiple Sleep Latency Tests. Absolute memory scores were not different between groups and were not correlated with HV in narcoleptics.
Narcoleptics had smaller bilateral HVs compared to controls. HV had a significant relationship with sleep and REM sleep latencies. This study provides supportive evidence of the functional and anatomical deficits in medial temporal areas that are related to the severity of narcolepsy.
背景/目的：本研究旨在比较发作性睡病患者与正常对照者的海马体积（HV）差异，并探讨 HV 与发作性睡病患者记忆功能的相关性。我们手动测量并比较了两组左、右 HV 和颅内体积（ICV）。
研究纳入 36 例未经药物治疗的伴猝倒发作的发作性睡病患者和 36 例年龄和性别匹配的正常对照者（平均年龄 29.0 岁）。所有受试者均接受 1.6mm 厚的扰相梯度回波磁共振成像检查，并接受韩国加利福尼亚词语学习测试和 Rey 复杂图形测试，以评估词语和视觉记忆。
两组间的平均 ICV 无差异（发作性睡病组 1599.2cm³，对照组 1623.5cm³，p =.450）。发作性睡病组双侧 HV 平均值明显较小（左侧，发作性睡病组 2907.2mm³，对照组 3092.3mm³，p = 0.005；右侧，发作性睡病组 2990.8mm³，对照组 3184.3mm³，p = 0.004）。校正性别、年龄和 ICV 后，两组间 HV 差异仍有统计学意义。在发作性睡病组中，双侧 HV 与多次睡眠潜伏期试验中的平均睡眠潜伏期和 REM 睡眠潜伏期呈正相关。两组间绝对记忆评分无差异，且与发作性睡病患者的 HV 无相关性。
与对照组相比，发作性睡病患者双侧 HV 较小。HV 与睡眠潜伏期和 REM 睡眠潜伏期显著相关。本研究为内侧颞叶区域的功能和解剖缺陷与发作性睡病严重程度相关提供了支持性证据。
