意大利男性橡胶轮胎工人队列的癌症和其他原因死亡率。

Mortality from cancer and other causes in an Italian cohort of male rubber tire workers.

机构信息

Dipartimento di Traumatologia, Ortopedia e Medicina del Lavoro, Università degli Studi di Torino, Turin, Italy.

出版信息

J Occup Environ Med. 2012 Mar;54(3):345-9. doi: 10.1097/JOM.0b013e318244503c.

DOI:10.1097/JOM.0b013e318244503c

PMID:22361990

Abstract

OBJECTIVE

To investigate mortality among workers of an Italian rubber tire factory employed between 1954 and 2008.

METHODS

This cohort study included 6246 men, totaling 190,512 man-years of observation. Employment data were obtained from personnel records, whereas vital status and causes of death were ascertained from local authorities. We computed standardized mortality ratios (SMRs) using national and regional death certification rates.

RESULTS

Mortality was significantly lower than expected for all cancers (SMR = 79) and all causes (SMR = 85). The SMRs were 99 for cancer of stomach, 78 for lung, 121 for urinary bladder, 116 for lymphoma, and 89 for leukemia, none being significant. Decreased mortality emerged for cancers of the oral cavity and pharynx (SMR = 45), esophagus (SMR = 29), colorectum (SMR = 71), liver (SMR = 57), and kidney (SMR = 33).

CONCLUSIONS

This study shows no excess cancer risk among male rubber tire workers employed after 1954.

摘要

目的

调查 1954 年至 2008 年期间在意大利一家橡胶轮胎厂工作的工人的死亡率。

方法

这项队列研究包括 6246 名男性，总计观察了 190512 人年。就业数据从人事记录中获得，而死亡人数和死因则从地方当局确定。我们使用国家和地区死亡证明率计算了标准化死亡率比（SMR）。

结果

所有癌症（SMR=79）和所有死因（SMR=85）的死亡率均显著低于预期。胃癌（SMR=99）、肺癌（SMR=78）、膀胱癌（SMR=121）、淋巴瘤（SMR=116）和白血病（SMR=89）的 SMR 均无显著差异。口腔和咽部（SMR=45）、食管（SMR=29）、结直肠（SMR=71）、肝脏（SMR=57）和肾脏（SMR=33）的癌症死亡率下降。