金钱松的细胞毒性成分：金钱松酸-A和-B及相关衍生物。
The cytotoxic principles of Pseudolarix kaempferi: pseudolaric acid-A and -B and related derivatives.
作者信息
Pan D J, Li Z L, Hu C Q, Chen K, Chang J J, Lee K H
机构信息
Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill 27599.
出版信息
Planta Med. 1990 Aug;56(4):383-5. doi: 10.1055/s-2006-960989.
Pseudolaric acid-A and -B, the novel diterpene acids isolated from Pseudolarix kaempferi, and their related derivatives have been tested for cytotoxicity against KB, A-549, HCT-8, P-388, and L-1210 tumor cells. The results showed that pseudolaric acid-A and -B demonstrated potent cytotoxicity. The selectivity of pseudolaric acid-A and -B which inhibit the growth of particular cell types within the disease-oriented human cancer cell line panels is discussed.
从金钱松中分离得到的新型二萜酸——土荆酸A和土荆酸B及其相关衍生物，已针对KB、A-549、HCT-8、P-388和L-1210肿瘤细胞进行了细胞毒性测试。结果表明，土荆酸A和土荆酸B具有很强的细胞毒性。本文讨论了土荆酸A和土荆酸B在以疾病为导向的人类癌细胞系组中抑制特定细胞类型生长的选择性。
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