黄芩中的细胞毒性新穿心莲烷二萜。
Cytotoxic neoclerodane diterpenoids from Scutellaria barbata.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.
出版信息
J Nat Prod. 2010 Feb 26;73(2):233-6. doi: 10.1021/np900309p.
Seven new neoclerodane diterpenoids, scutebatas A-G (1-7), have been isolated from Scutellaria barbata. Compounds 1-3 possess a rare alpha-hydroxy group in their alpha,beta-unsaturated lactone rings. Their structures were elucidated by spectroscopic analysis, and the relative configuration of scutebata A was deduced using ROESY data and the computational DFT method. Compounds 1, 2, 4, 5, and 6 were evaluated for in vitro cytotoxicity against six human cancer cell lines: HL-60, SMMC-7721, A-549, SK-BR-3, CACO-2, and PANC-1. Scutebata A (1) showed weak cytotoxicity against SK-BR-3 with an IC(50) value of 15.2 muM.
从黄芩中分离得到了 7 个新的新穿心莲烷二萜类化合物，分别命名为 scutebatas A-G（1-7）。化合物 1-3 在其 α,β-不饱和内酯环中具有罕见的α-羟基基团。通过光谱分析阐明了它们的结构，并根据 ROESY 数据和计算的 DFT 方法推导出 scutebata A 的相对构型。对化合物 1、2、4、5 和 6 进行了体外细胞毒性评价，针对 6 个人类癌细胞系：HL-60、SMMC-7721、A-549、SK-BR-3、CACO-2 和 PANC-1。Scutebata A（1）对 SK-BR-3 表现出较弱的细胞毒性，IC50 值为 15.2 μM。
Zotero 插件