Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Int Wound J. 2013 Feb;10(1):105-9. doi: 10.1111/j.1742-481X.2012.00951.x. Epub 2012 Feb 24.
Chronic osteomyelitis associated with soft-tissue defect following surgical management is a severe complication for orthopaedic surgeons. Traditionally, the treatment protocol for the notorious complication involved thorough debridement, bone grafting, long-term antibiotic use and flap surgery. Alternatively, platelet-rich plasma (PRP), a high concentration of platelets collected via centrifugation, has been successfully used as an adjuvant treatment for bone and soft-tissue infection in medical practices. PRP has numerous significant advantages, including stypsis, inflammation remission and reducing the amount of infected fluid. It increases bone and soft-tissue healing and allows fewer opportunities for transplant rejection. Through many years of studies showing the advantages of PRP, it has become preferred organic product for the clinical treatment of infections, especially for chronic osteomyelitis associated with soft-tissue defect. To promote the clinical use of this simple and efficacious technique in trauma, we report the case of a patient with chronic calcaneal osteomyelitis associated with soft-tissue defect that healed uneventfully with PRP.
慢性骨髓炎伴软组织缺损是骨科医生面临的严重并发症。传统上,对于这种臭名昭著的并发症的治疗方案包括彻底清创、植骨、长期使用抗生素和皮瓣手术。相反,富血小板血浆(PRP)是通过离心收集的高浓度血小板,已成功地用于医学实践中骨和软组织感染的辅助治疗。PRP 有许多显著的优点,包括止血、缓解炎症和减少感染液的量。它可以促进骨和软组织的愈合,减少移植排斥的机会。通过多年的研究表明 PRP 的优势,它已成为感染临床治疗的首选有机产品,特别是对于慢性跟骨骨髓炎伴软组织缺损。为了促进这项简单有效的技术在创伤中的临床应用,我们报告了一例慢性跟骨骨髓炎伴软组织缺损的患者,使用 PRP 后愈合顺利。