Johannessen Rune, Petersen Hermod, Sue-Chu Malcolm, Aasebøstøl Anne Kristin, Løge Ingard, Kleveland Per Martin
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Unit for Gastroenterology, Trondheim, Norway.
Scand J Gastroenterol. 2012 May;47(5):499-508. doi: 10.3109/00365521.2012.660543. Epub 2012 Feb 27.
Airway symptoms and sleeplessness in patients with gastroesophageal reflux disease (GERD) may be of importance. This study validates a new questionnaire dealing with such symptoms.
The Reflux, Airway and Sleep Questionnaire (RASQ) is self-administered, asks about 18 symptoms or diagnoses possibly related to GERD answered on a seven-point Likert scale and with a 1-year recall period. There are questions about heartburn/regurgitation, sleeplessness, snoring, pneumonia, and upper airway infections, as well as various bronchial and laryngeal symptoms. The study included 305 patients diagnosed with GERD (n = 65), laryngitis (n = 32), asthma (n = 30), chronic obstructive pulmonary disease (n = 45), acute bronchitis (n = 39), pneumonia (n = 42), or upper airway infection (n = 52) during the last year, and 708 matched healthy controls. Concurrent validity was based on comparisons between patients and controls. Convergent validity for sleeplessness and snoring were tested by comparing the RASQ with the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS). Test-retest reliability was examined in patients with GERD with stable symptoms (n = 29).
Response rates were 64% for patients and 55% for controls. Scores for RASQ as a total and all subscales were significantly higher in patients than in controls. Sleeplessness scores correlated significantly to the global PSQI score. Snoring correlated significantly with both the ESS and relevant aspects of the PSQI. Test-retest reliability and Cronbach's alpha were satisfactory, with coefficients ranging between 0.65-0.95 and 0.88-0.92, respectively.
The RASQ appears to be well suited for measuring typical reflux symptoms as well as airway symptoms and sleep disturbances.
胃食管反流病（GERD）患者的气道症状和失眠可能具有重要意义。本研究验证了一份针对此类症状的新问卷。
反流、气道和睡眠问卷（RASQ）为自填式问卷，询问18种可能与GERD相关的症状或诊断，采用七点李克特量表作答，回顾期为1年。问卷涉及烧心/反流、失眠、打鼾、肺炎和上呼吸道感染，以及各种支气管和喉部症状。该研究纳入了305例在过去一年中被诊断为GERD（n = 65）、喉炎（n = 32）、哮喘（n = 30）、慢性阻塞性肺疾病（n = 45）、急性支气管炎（n = 39）、肺炎（n = 42）或上呼吸道感染（n = 52）的患者，以及708名匹配的健康对照。同时效度基于患者与对照之间的比较。通过将RASQ与匹兹堡睡眠质量指数（PSQI）和爱泼华嗜睡量表（ESS）进行比较，测试失眠和打鼾的收敛效度。在症状稳定的GERD患者（n = 29）中检验重测信度。
患者的应答率为64%，对照的应答率为55%。患者的RASQ总分及所有子量表得分均显著高于对照。失眠得分与PSQI总体得分显著相关。打鼾与ESS及PSQI的相关方面均显著相关。重测信度和克朗巴哈系数均令人满意，系数分别在0.65 - 0.95和0.88 - 0.92之间。
RASQ似乎非常适合用于测量典型的反流症状以及气道症状和睡眠障碍。
