Nuclear Medicine Unit, Department of Internal Medicine, San Martino University Hospital, Genoa, Italy.
Neurobiol Aging. 2012 Nov;33(11):2533-50. doi: 10.1016/j.neurobiolaging.2012.01.005. Epub 2012 Feb 23.
We explored resting-state metabolic connectivity in prodromal Alzheimer's disease (pAD) patients and in healthy controls (CTR), through a voxel-wise interregional correlation analysis of 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) by means of statistical parametric mapping. Baseline 18F-fluorodeoxyglucose-positron emission tomography of 36 patients with amnestic mild cognitive impairment who converted to Alzheimer's disease (AD) dementia after an average time of 2 years (pAD) and of 105 CTR were processed. The area of hypometabolism in pAD showed less metabolic connectivity in patients than in CTR (autocorrelation and correlation with large temporal and frontal areas, respectively). pAD patients showed limited correlation even in selected nonhypometabolic areas, including the hippocampi and the dorsolateral prefrontal cortex (DLFC). On the contrary, in CTR group correlation was highlighted between hippocampi and precuneus/posterior cingulate and frontal cortex, and between dorsolateral prefrontal cortex and caudate nuclei and parietal cortex. The reduced metabolic connections both in hypometabolic and nonhypometabolic areas in pAD patients suggest that metabolic disconnection (reflecting early diaschisis) may antedate remote hypometabolism (early sign of synaptic degeneration).
我们通过统计参数映射，对 18F-氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）的 18F-氟脱氧葡萄糖-PET 进行区域间相关分析，探讨了前驱期阿尔茨海默病（pAD）患者和健康对照（CTR）的静息状态代谢连通性。对平均 2 年后转化为阿尔茨海默病（AD）痴呆的 36 例遗忘性轻度认知障碍患者（pAD）和 105 例 CTR 的基线 18F-氟脱氧葡萄糖-PET 进行了处理。与 CTR 相比，pAD 患者的低代谢区显示出更少的代谢连通性（自相关和与大时间和额区的相关性）。即使在包括海马体和背外侧前额叶皮层（DLFC）在内的选定非低代谢区，pAD 患者的相关性也很有限。相比之下，在 CTR 组中，海马体与楔前叶/后扣带回和额叶皮层之间，以及背外侧前额叶皮层与尾状核和顶叶皮层之间的相关性较强。pAD 患者在低代谢和非低代谢区的代谢连接减少表明，代谢失连接（反映早期远隔区失活）可能先于远程低代谢（突触退化的早期迹象）。
