The Queensland Institute of Medical Research, The Bancroft Centre, 300 Herston Road, Brisbane, Queensland 4006, Australia.
Trends Parasitol. 2012 May;28(5):182-6. doi: 10.1016/j.pt.2012.01.007. Epub 2012 Feb 25.
Dendritic cells (DCs), the sentinels of immunity, reside in almost every organ of the body. These cells are responsible for initiating immune responses against infectious agents. DCs are divided into different subsets based on their biological functions, with plasmacytoid DCs (pDCs) and conventional DCs (cDCs) being two major populations. The ability of DCs to protect against malaria infection was recently questioned when pDCs were reported to be a reservoir for rodent Plasmodium spp. in the spleen. This opinion article explores how the occupation of pDCs by the parasite may corrupt immunity against malaria.
树突状细胞（DCs）是免疫的哨兵，存在于几乎身体的每个器官中。这些细胞负责启动针对感染因子的免疫反应。根据其生物学功能，DC 可分为不同亚群，其中浆细胞样树突状细胞（pDCs）和传统树突状细胞（cDCs）是两个主要群体。当报道 pDCs 是脾脏中啮齿动物疟原虫的储存库时，最近对 DCs 抵抗疟疾感染的能力提出了质疑。这篇观点文章探讨了寄生虫占据 pDCs 如何可能破坏对疟疾的免疫。
