Department of Radiation Oncology, General Hospital of Ningxia Medical University, Yinchuan, No. 804 Shengli Str, Yinchuan, 750004, Ningxia, China.
Department of Surgical Oncology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
World J Surg. 2012 May;36(5):1189-1194. doi: 10.1007/s00268-012-1514-3.
The purpose of present study was to examine the expression of cancer stem cell marker Bmi-1 in breast cancer tissue and to evaluate the clinical implication of Bmi-1 expression for these patients.
A total of 171 breast cancer patients who received surgical treatment in our hospital were enrolled in this study. Bmi-1 expression in breast cancer tissue was assayed by immunohistochemistry. Statistical analyses were applied to test the relationship between expression of Bmi-1 and clinicopathologic features and patient survival. The relationship between Bmi-1 and the basal-like phenotype of breast cancer also was analyzed in this study.
Positive Bmi-1 expression was detected in 89 of 171 (52%) invasive breast cancers patients. The Bmi-1 status was significantly correlated to histological grade III (p = 0.001) and basal-like phenotype (p < 0.001). The 5 year overall survival of the patients with Bmi-1-positive and -negative cancers were 78 and 91.9%, respectively (p = 0.03). Histological grade (p = 0.046) and Bmi-1 status (p = 0.012) were detected as the independent prognostic factors in the Cox regression test.
Bmi-1 status is an independent prognostic factor, which also is associated with tumor histological grade and basal-like phenotype. The high proportions of positive Bmi-1 expression in basal-like breast cancer may be related to the high aggressiveness behavior of this subtype of breast cancer.
本研究旨在检测乳腺癌组织中癌症干细胞标志物 Bmi-1 的表达，并评估 Bmi-1 表达对这些患者的临床意义。
本研究共纳入 171 例在我院接受手术治疗的乳腺癌患者。采用免疫组织化学法检测乳腺癌组织中 Bmi-1 的表达。应用统计学分析检测 Bmi-1 表达与临床病理特征和患者生存之间的关系。本研究还分析了 Bmi-1 与乳腺癌基底样表型之间的关系。
在 171 例浸润性乳腺癌患者中，89 例（52%）检测到 Bmi-1 阳性表达。Bmi-1 状态与组织学分级 III（p = 0.001）和基底样表型（p < 0.001）显著相关。Bmi-1 阳性和阴性癌症患者的 5 年总生存率分别为 78%和 91.9%（p = 0.03）。组织学分级（p = 0.046）和 Bmi-1 状态（p = 0.012）是 Cox 回归检验中独立的预后因素。
Bmi-1 状态是一个独立的预后因素，与肿瘤组织学分级和基底样表型相关。基底样乳腺癌中 Bmi-1 阳性表达率较高，可能与该亚型乳腺癌侵袭性较高有关。
