天然产物分离的后续研究。

Follow-up of natural products isolation.

作者信息

Cannell Richard J P, Sarker Satyajit D, Nahar Lutfun

机构信息

Department of Pharmacy, School of Applied Sciences, University of Wolverhampton, Wolverhampton, WV11LY, UK.

出版信息

Methods Mol Biol. 2012;864:473-514. doi: 10.1007/978-1-61779-624-1_19.

DOI:10.1007/978-1-61779-624-1_19

PMID:22367909

Abstract

Follow-up of natural products isolation refers to re-isolation of compound(s) of interest in larger amounts for further pharmacological testing, conclusive structure elucidation, structure modifications to synthesize analogs for structure-activity relationships (SAR) studies, preformulation and formulation studies or clinical trials. In addition to conventional synthetic chemistry approaches, several other methodologies can be applied for following-up natural products isolation. This chapter outlines, with specific examples, various strategies and methods involved in follow-up of natural products isolation.

摘要

天然产物分离的后续研究是指再次分离出大量感兴趣的化合物，用于进一步的药理测试、最终的结构解析、进行结构修饰以合成类似物用于构效关系（SAR）研究、制剂前研究和制剂研究或临床试验。除了传统的合成化学方法外，还可以应用其他几种方法进行天然产物分离的后续研究。本章通过具体实例概述了天然产物分离后续研究中涉及的各种策略和方法。