Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, People's Republic of China.
Nat Prod Rep. 2021 Oct 20;38(10):1775-1793. doi: 10.1039/d0np00069h.
Covering: up to July 2020Fungal metabolites with diverse and novel scaffolds can be assembled from well-known biosynthetic precursors through various mechanisms. Recent examples of novel alkaloids (, cytochalasans and diketopiperazine derivatives), terpenes (, sesterterpenes and diterpenes) and polyketides produced by fungi are presented through case studies. We show that large-scale culture is a complementary and practical method for genome mining and OSMAC approaches to discover natural products of unprecedented skeletal classes from fungi. We also summarize the discovery strategies and challenges for characterizing these compounds.
截至 2020 年 7 月，真菌代谢产物具有多样新颖的骨架结构，可以通过多种机制从已知的生物合成前体中组装而成。通过案例研究，介绍了真菌产生的新型生物碱（细胞松弛素和二酮哌嗪衍生物）、萜类化合物（倍半萜和二萜）和聚酮类化合物。我们表明，大规模培养是基因组挖掘和 OSMAC 方法的补充和实用方法，可以从真菌中发现具有空前骨架类别的天然产物。我们还总结了这些化合物的发现策略和表征挑战。
