Department of Cognitive, Linguistic, and Psychological Sciences, Brown University, Providence, RI 02912, USA.
Cereb Cortex. 2013 Feb;23(2):460-76. doi: 10.1093/cercor/bhs038. Epub 2012 Feb 23.
We examined the cytoarchitectonic and chemoarchitectonic organization of the cortical regions associated with the posterior rhinal fissure in the mouse brain, within the framework of what is known about these regions in the rat. Primary observations were in a first-generation hybrid mouse line, B6129PF/J1. The F1 hybrid was chosen because of the many advantages afforded in the study of the molecular and cellular bases of learning and memory. Comparisons with the parent strains, the C57BL6/J and 129P3/J are also reported. Mouse brain tissue was processed for visualization of Nissl material, myelin, acetyl cholinesterase, parvalbumin, and heavy metals. Tissue stained for heavy metals by the Timm's method was particularly useful in the assignment of borders and in the comparative analyses because the patterns of staining were similar across species and strains. As in the rat, the areas examined were parcellated into 2 regions, the perirhinal and the postrhinal cortices. The perirhinal cortex was divided into areas 35 and 36, and the postrhinal cortex was divided into dorsal (PORd) and ventral (PORv) subregions. In addition to identifying the borders of the perirhinal cortex, we were able to identify a region in the mouse brain that shares signature features with the rat postrhinal cortex.
我们在第一代杂交鼠 B6129PF/J1 中，以已知的大鼠相应区域为框架，研究了与鼠脑后侧裂相关的皮质区域的细胞构筑和化学构筑组织。选择 F1 杂交鼠是因为它在研究学习和记忆的分子和细胞基础方面具有许多优势。还报告了与亲代品系 C57BL6/J 和 129P3/J 的比较。对鼠脑组织进行尼氏物质、髓鞘、乙酰胆碱酯酶、副甲状腺球蛋白和重金属的可视化处理。用 Timm 法染色的重金属组织在边界分配和比较分析中特别有用，因为染色模式在不同物种和品系之间相似。与大鼠一样，所检查的区域被划分为两个区域，即边缘区和后缘区。边缘区被分为 35 区和 36 区，后缘区被分为背侧（PORd）和腹侧（PORv）亚区。除了确定边缘区的边界外，我们还能够在鼠脑中确定一个与大鼠后缘区具有特征性相似特征的区域。
