Foster T S, Raehl C L, Wilson H D
Am J Hosp Pharm. 1980 Jun;37(6):858-9.
A disulfiram-like reaction attributed to cefoperazone, an investigational cephalosporin, is reported. Cefoperazone (T-1551, Pfizer Pharmaceuticals, Inc.), a semisynthetic, parenteral cephalosporin undergoing clinical trials in the United States, was administered in single 1-, 2-, and 3-g doses to 12 healthy volunteers. The drug was administered as a 5% solution by constant infusion over a five-minute period, and one week was allowed between doses. Approximately 25 hours after receiving the 3-g dose, one subject experienced facial flushing after drinking 12 fluid ounces of beer. A second ingestion of 24 ounces of beer eight hours later produced facial flushing, tachycardia, diaphoresis, and pounding headache; the symptoms lasted 1.5-2 hours. A subsequent rechallenge with beer five hours later produced an identical reaction, but the symptoms subsided rapidly. Further rechallenge 60 hours after receiving the drug produced no ill effects. No such reaction appears to have been reported previously as being associated with the administration of a cephalosporin.
据报道，一种正在研究的头孢菌素头孢哌酮可引发双硫仑样反应。头孢哌酮（T - 1551，辉瑞制药公司）是一种半合成的肠外头孢菌素，正在美国进行临床试验，以单次1克、2克和3克剂量给予12名健康志愿者。药物以5%溶液的形式在5分钟内持续输注给药，两次给药间隔一周。在接受3克剂量约25小时后，一名受试者饮用12液量盎司啤酒后出现面部潮红。8小时后再次饮用24盎司啤酒，出现面部潮红、心动过速、出汗和剧烈头痛；症状持续1.5 - 2小时。5小时后再次用啤酒激发产生相同反应，但症状迅速消退。用药60小时后再次激发未产生不良影响。此前似乎没有报道过与头孢菌素给药相关的此类反应。
