Kul'chitskiĭ O K
Vopr Med Khim. 1981 Jan-Feb;27(1):40-3.
Content and the ratio of cAMP/cGMP in myocardium, liver tissue and sceletal muscle were similar in adult and old rats. Adrenaline (5 . 10(-6) M) caused more distinct increase in content of cAMP in the old animals. After treatment with NaF (0.01 M) the age differences in the cAMP content were observed only in the heart muscle. Adrenaline appears to activate most effectively adenylate cyclase in tissues of old rats; the enzyme is apparently responsible for enhanced sensitivity to the hormone in senile age.
成年大鼠和老年大鼠心肌、肝组织及骨骼肌中cAMP/cGMP的含量及比例相似。肾上腺素（5×10⁻⁶ M）使老年动物的cAMP含量增加更为明显。用氟化钠（0.01 M）处理后，仅在心肌中观察到cAMP含量的年龄差异。肾上腺素似乎能最有效地激活老年大鼠组织中的腺苷酸环化酶；该酶显然是导致老年时对该激素敏感性增强的原因。
